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ORCA-010, a Novel Potency-Enhanced Oncolytic Adenovirus, Exerts Strong Antitumor Activity in Preclinical Models

Improving the antitumor potency of current oncolytic adenoviruses represents one of the major challenges in development of these viruses for clinical use. We have generated an oncolytic adenovirus carrying the safety-enhancing E1AΔ24 deletion, the potency-enhancing T1 mutation, and the infectivity-e...

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書誌詳細
主要な著者: Dong, Wenliang, van Ginkel, Jan-Willem H., Au, Kam Y., Alemany, Ramon, Meulenberg, Janneke J.M., van Beusechem, Victor W.
フォーマット: Artigo
言語:Inglês
出版事項: Mary Ann Liebert, Inc. 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180126/
https://ncbi.nlm.nih.gov/pubmed/25093639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2013.229
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