ORCA-010, a Novel Potency-Enhanced Oncolytic Adenovirus, Exerts Strong Antitumor Activity in Preclinical Models

Improving the antitumor potency of current oncolytic adenoviruses represents one of the major challenges in development of these viruses for clinical use. We have generated an oncolytic adenovirus carrying the safety-enhancing E1AΔ24 deletion, the potency-enhancing T1 mutation, and the infectivity-e...

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Detaylı Bibliyografya
Asıl Yazarlar: Dong, Wenliang, van Ginkel, Jan-Willem H., Au, Kam Y., Alemany, Ramon, Meulenberg, Janneke J.M., van Beusechem, Victor W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Mary Ann Liebert, Inc. 2014
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180126/
https://ncbi.nlm.nih.gov/pubmed/25093639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2013.229
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