ORCA-010, a Novel Potency-Enhanced Oncolytic Adenovirus, Exerts Strong Antitumor Activity in Preclinical Models

Improving the antitumor potency of current oncolytic adenoviruses represents one of the major challenges in development of these viruses for clinical use. We have generated an oncolytic adenovirus carrying the safety-enhancing E1AΔ24 deletion, the potency-enhancing T1 mutation, and the infectivity-e...

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Dettagli Bibliografici
Autori principali: Dong, Wenliang, van Ginkel, Jan-Willem H., Au, Kam Y., Alemany, Ramon, Meulenberg, Janneke J.M., van Beusechem, Victor W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2014
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180126/
https://ncbi.nlm.nih.gov/pubmed/25093639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2013.229
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