A Multifunctional LNA Oligonucleotide-Based Strategy Blocks AR Expression and Transactivation Activity in PCa Cells

The androgen receptor (AR) plays a critical role in the development of prostate cancer (PCa) through the activation of androgen-induced cellular proliferation genes. Thus, blocking AR-mediated transcriptional activation is expected to inhibit the growth and spread of PCa. Using tailor-made splice-sw...

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Pubblicato in:Mol Ther Nucleic Acids
Autori principali: Castanotto, Daniela, Zhang, Xiaowei, Rüger, Jacqueline, Alluin, Jessica, Sharma, Ritin, Pirrotte, Patrick, Joenson, Lars, Ioannou, Silvia, Nelson, Michael S., Vikeså, Jonas, Hansen, Bo Rode, Koch, Troels, Jensen, Mads Aaboe, Rossi, John J., Stein, Cy A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2020
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7723773/
https://ncbi.nlm.nih.gov/pubmed/33335793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.10.032
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