Inhibitory designer receptors aggravate memory loss in a mouse model of down syndrome

The pontine nucleus locus coeruleus (LC) is the primary source of noradrenergic (NE) projections to the brain and is important for working memory, attention, and cognitive flexibility. Individuals with Down syndrome (DS) develop Alzheimer's disease (AD) with high penetrance and often exhibit wo...

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Bibliografiska uppgifter
I publikationen:Neurobiol Dis
Huvudupphovsmän: Hamlett, Eric D., Ledreux, Aurélie, Gilmore, Anah, Vazey, Elena M., Aston-Jones, Gary, Boger, Heather A., Paredes, Daniel, Granholm, Ann-Charlotte E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7722242/
https://ncbi.nlm.nih.gov/pubmed/31678403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.104616
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