Inhibitory designer receptors aggravate memory loss in a mouse model of down syndrome

The pontine nucleus locus coeruleus (LC) is the primary source of noradrenergic (NE) projections to the brain and is important for working memory, attention, and cognitive flexibility. Individuals with Down syndrome (DS) develop Alzheimer's disease (AD) with high penetrance and often exhibit wo...

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Veröffentlicht in:Neurobiol Dis
Hauptverfasser: Hamlett, Eric D., Ledreux, Aurélie, Gilmore, Anah, Vazey, Elena M., Aston-Jones, Gary, Boger, Heather A., Paredes, Daniel, Granholm, Ann-Charlotte E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7722242/
https://ncbi.nlm.nih.gov/pubmed/31678403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.104616
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