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Deficiency in Acyl-CoA:Wax Alcohol Acyltransferase 2 causes evaporative dry eye disease by abolishing biosynthesis of wax esters

Lipids secreted by the meibomian glands (MGs) of the eyelids are essential to the protection of the eye’s surface. An altered meibum composition represents the primary cause of evaporative dry eye disease (DED). Despite the critical importance of the meibum, its biosynthetic pathways and the roles o...

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Bibliografski detalji
Izdano u:FASEB J
Glavni autori: Widjaja-Adhi, Made Airanthi K., Silvaroli, Josie A., Chelstowska, Sylwia, Trischman, Thomas, Bederman, Ilya, Sayegh, Rony, Golczak, Marcin
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7722226/
https://ncbi.nlm.nih.gov/pubmed/32851726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.202001191R
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