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Impact of LCA-Associated E14L LRAT Mutation on Protein Stability and Retinoid Homeostasis
Vitamin A (all-trans-retinol) is metabolized to the visual chromophore (11-cis-retinal) in the eyes and to all-trans-retinoic acid, a hormone like compound, in most tissues. A key enzyme in retinoid metabolism is lecithin:retinol acyltransferase (LRAT), which catalyzes the esterification of vitamin...
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| Udgivet i: | Biochemistry |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5682948/ https://ncbi.nlm.nih.gov/pubmed/28758396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00451 |
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