Nonlinear interaction between APOE ε4 allele load and age in the hippocampal surface of cognitively intact individuals

The ε4 allele of the gene Apolipoprotein E is the major genetic risk factor for Alzheimer's Disease. APOE ε4 has been associated with changes in brain structure in cognitively impaired and unimpaired subjects, including atrophy of the hippocampus, which is one of the brain structures that is ea...

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Veröffentlicht in:Hum Brain Mapp
Hauptverfasser: Martí‐Juan, Gerard, Sanroma‐Guell, Gerard, Cacciaglia, Raffaele, Falcon, Carles, Operto, Grégory, Molinuevo, José Luis, González Ballester, Miguel Ángel, Gispert, Juan Domingo, Piella, Gemma
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Inc. 2020
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7721244/
https://ncbi.nlm.nih.gov/pubmed/33017488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hbm.25202
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