White matter microstructure is altered in cognitively normal middle-aged APOE-ε4 homozygotes

BACKGROUND: The ε4 allele of the apolipoprotein E gene (APOE-ε4) is the strongest genetic factor for late-onset Alzheimer’s disease. During middle age, cognitively healthy APOE-ε4 carriers already show several brain alterations that resemble those of Alzheimer's disease (AD), but to a subtler d...

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Detalhes bibliográficos
Publicado no:Alzheimers Res Ther
Main Authors: Operto, Grégory, Cacciaglia, Raffaele, Grau-Rivera, Oriol, Falcon, Carles, Brugulat-Serrat, Anna, Ródenas, Pablo, Ramos, Rubén, Morán, Sebastián, Esteller, Manel, Bargalló, Nuria, Molinuevo, José Luis, Gispert, Juan Domingo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5968505/
https://ncbi.nlm.nih.gov/pubmed/29793545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-018-0375-x
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