APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals

The APOE-ε4 genotype is the highest genetic risk factor for Alzheimer's disease (AD). In cognitively unimpaired individuals, it has been related to altered brain morphology, function and earlier amyloid beta accumulation. However, its impact on cognitive performance is less evident. Here, we ex...

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Detalhes bibliográficos
Publicado no:Neuroimage Clin
Main Authors: Cacciaglia, Raffaele, Molinuevo, José Luis, Falcón, Carles, Sánchez-Benavides, Gonzalo, Gramunt, Nina, Brugulat-Serrat, Anna, Esteller, Manel, Morán, Sebastián, Fauria, Karine, Gispert, Juan Domingo
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463204/
https://ncbi.nlm.nih.gov/pubmed/30991302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nicl.2019.101818
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