APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals

The APOE-ε4 genotype is the highest genetic risk factor for Alzheimer's disease (AD). In cognitively unimpaired individuals, it has been related to altered brain morphology, function and earlier amyloid beta accumulation. However, its impact on cognitive performance is less evident. Here, we ex...

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Bibliographic Details
Published in:Neuroimage Clin
Main Authors: Cacciaglia, Raffaele, Molinuevo, José Luis, Falcón, Carles, Sánchez-Benavides, Gonzalo, Gramunt, Nina, Brugulat-Serrat, Anna, Esteller, Manel, Morán, Sebastián, Fauria, Karine, Gispert, Juan Domingo
Format: Artigo
Language:Inglês
Published: Elsevier 2019
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Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463204/
https://ncbi.nlm.nih.gov/pubmed/30991302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nicl.2019.101818
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