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Structural analysis of the polo-box domain of human Polo-like kinase 2

Polo-like kinases (Plks) are the key regulators of cell cycle progression, the members of which share a kinase domain and a polo-box domain (PBD) that serves as a protein-binding module. While Plk1 is a promising target for antitumor therapy, Plk2 is regarded as a tumor suppressor even though the tw...

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Publicat a:Proteins
Autors principals: Kim, Ju Hee, Ku, Bonsu, Lee, Kyung S., Kim, Seung Jun
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7720676/
https://ncbi.nlm.nih.gov/pubmed/25846005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24804
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