Computational-based Engineering of Cytochrome P450 MycG for Selective Oxidation of 16-membered Macrolide Antibiotics

MycG is a cytochrome P450 that performs two sequential oxidation reactions on the 16-membered ring macrolide M-IV. The enzyme evolved to oxidize M-IV preferentially over M-III and M-VI, which differ structurally by the presence of methoxy vs free hydroxyl groups on one of the macrolide sugar moietie...

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Vydáno v:J Am Chem Soc
Hlavní autoři: Yang, Song, DeMars, Matthew D., Grandner, Jessica M., Olson, Noelle M., Anzai, Yojiro, Sherman, David H., Houk, K. N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7720209/
https://ncbi.nlm.nih.gov/pubmed/33030347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c04388
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