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Computational-based Engineering of Cytochrome P450 MycG for Selective Oxidation of 16-membered Macrolide Antibiotics
MycG is a cytochrome P450 that performs two sequential oxidation reactions on the 16-membered ring macrolide M-IV. The enzyme evolved to oxidize M-IV preferentially over M-III and M-VI, which differ structurally by the presence of methoxy vs free hydroxyl groups on one of the macrolide sugar moietie...
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| Udgivet i: | J Am Chem Soc |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7720209/ https://ncbi.nlm.nih.gov/pubmed/33030347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c04388 |
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