Exo1 recruits Cdc5 polo kinase to MutLγ to ensure efficient meiotic crossover formation

Crossovers generated during the repair of programmed meiotic double-strand breaks must be tightly regulated to promote accurate homolog segregation without deleterious outcomes, such as aneuploidy. The Mlh1–Mlh3 (MutLγ) endonuclease complex is critical for crossover resolution, which involves mechan...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Sanchez, Aurore, Adam, Céline, Rauh, Felix, Duroc, Yann, Ranjha, Lepakshi, Lombard, Bérangère, Mu, Xiaojing, Wintrebert, Mélody, Loew, Damarys, Guarné, Alba, Gnan, Stefano, Chen, Chun-Long, Keeney, Scott, Cejka, Petr, Guérois, Raphaël, Klein, Franz, Charbonnier, Jean-Baptiste, Borde, Valérie
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7720183/
https://ncbi.nlm.nih.gov/pubmed/33199619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2013012117
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