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Concerted action of the MutLβ heterodimer and Mer3 helicase regulates the global extent of meiotic gene conversion

Gene conversions resulting from meiotic recombination are critical in shaping genome diversification and evolution. How the extent of gene conversions is regulated is unknown. Here we show that the budding yeast mismatch repair related MutLβ complex, Mlh1-Mlh2, specifically interacts with the conser...

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Veröffentlicht in:eLife
Hauptverfasser: Duroc, Yann, Kumar, Rajeev, Ranjha, Lepakshi, Adam, Céline, Guérois, Raphaël, Md Muntaz, Khan, Marsolier-Kergoat, Marie-Claude, Dingli, Florent, Laureau, Raphaëlle, Loew, Damarys, Llorente, Bertrand, Charbonnier, Jean-Baptiste, Cejka, Petr, Borde, Valérie
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215242/
https://ncbi.nlm.nih.gov/pubmed/28051769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21900
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