Alpha-Synuclein Oligomers and Neurofilament Light Chain in Spinal Fluid Differentiate Multiple System Atrophy from Lewy Body Synucleinopathies

OBJECTIVE: To explore the role of alpha-synuclein (αSyn) oligomers and neurofilament light chain (NFL) in cerebrospinal fluid (CSF) as markers of early multiple system atrophy (MSA) and to contrast findings with Lewy body synucleinopathies. METHODS: In a discovery cohort of well-characterized early...

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Bibliografiska uppgifter
I publikationen:Ann Neurol
Huvudupphovsmän: Singer, Wolfgang, Schmeichel, Ann M., Shahnawaz, Mohammad, Schmelzer, James D., Boeve, Bradley F., Sletten, David M., Gehrking, Tonette L., Gehrking, Jade A., Olson, Anita D., Savica, Rodolfo, Suarez, Mariana D., Soto, Claudio, Low, Phillip A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7719613/
https://ncbi.nlm.nih.gov/pubmed/32557811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.25824
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