Alpha-Synuclein Oligomers and Neurofilament Light Chain in Spinal Fluid Differentiate Multiple System Atrophy from Lewy Body Synucleinopathies

OBJECTIVE: To explore the role of alpha-synuclein (αSyn) oligomers and neurofilament light chain (NFL) in cerebrospinal fluid (CSF) as markers of early multiple system atrophy (MSA) and to contrast findings with Lewy body synucleinopathies. METHODS: In a discovery cohort of well-characterized early...

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Publié dans:Ann Neurol
Auteurs principaux: Singer, Wolfgang, Schmeichel, Ann M., Shahnawaz, Mohammad, Schmelzer, James D., Boeve, Bradley F., Sletten, David M., Gehrking, Tonette L., Gehrking, Jade A., Olson, Anita D., Savica, Rodolfo, Suarez, Mariana D., Soto, Claudio, Low, Phillip A.
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7719613/
https://ncbi.nlm.nih.gov/pubmed/32557811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.25824
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