Alpha-Synuclein Oligomers and Neurofilament Light Chain in Spinal Fluid Differentiate Multiple System Atrophy from Lewy Body Synucleinopathies

OBJECTIVE: To explore the role of alpha-synuclein (αSyn) oligomers and neurofilament light chain (NFL) in cerebrospinal fluid (CSF) as markers of early multiple system atrophy (MSA) and to contrast findings with Lewy body synucleinopathies. METHODS: In a discovery cohort of well-characterized early...

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Udgivet i:Ann Neurol
Main Authors: Singer, Wolfgang, Schmeichel, Ann M., Shahnawaz, Mohammad, Schmelzer, James D., Boeve, Bradley F., Sletten, David M., Gehrking, Tonette L., Gehrking, Jade A., Olson, Anita D., Savica, Rodolfo, Suarez, Mariana D., Soto, Claudio, Low, Phillip A.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7719613/
https://ncbi.nlm.nih.gov/pubmed/32557811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.25824
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