DNA methyltransferase 3B plays a protective role against hepatocarcinogenesis caused by chronic inflammation via maintaining mitochondrial homeostasis

Most hepatocellular carcinomas (HCCs) develop on the basis of chronic hepatitis, but the mechanism of epigenetic regulation in inflammatory hepatocarcinogenesis has yet to be elucidated. Among de novo DNA methyltransferases (DNMTs), DNMT3B has lately been reported to act specifically on actively tra...

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Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Iguchi, Eriko, Takai, Atsushi, Takeda, Haruhiko, Kumagai, Ken, Arasawa, Soichi, Eso, Yuji, Shimizu, Takahiro, Ueda, Yoshihide, Marusawa, Hiroyuki, Seno, Hiroshi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2020
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7719166/
https://ncbi.nlm.nih.gov/pubmed/33277576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78151-2
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