DNA methyltransferase 3B plays a protective role against hepatocarcinogenesis caused by chronic inflammation via maintaining mitochondrial homeostasis

Most hepatocellular carcinomas (HCCs) develop on the basis of chronic hepatitis, but the mechanism of epigenetic regulation in inflammatory hepatocarcinogenesis has yet to be elucidated. Among de novo DNA methyltransferases (DNMTs), DNMT3B has lately been reported to act specifically on actively tra...

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Pubblicato in:Sci Rep
Autori principali: Iguchi, Eriko, Takai, Atsushi, Takeda, Haruhiko, Kumagai, Ken, Arasawa, Soichi, Eso, Yuji, Shimizu, Takahiro, Ueda, Yoshihide, Marusawa, Hiroyuki, Seno, Hiroshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7719166/
https://ncbi.nlm.nih.gov/pubmed/33277576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78151-2
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