DNA methyltransferase 3B plays a protective role against hepatocarcinogenesis caused by chronic inflammation via maintaining mitochondrial homeostasis

Most hepatocellular carcinomas (HCCs) develop on the basis of chronic hepatitis, but the mechanism of epigenetic regulation in inflammatory hepatocarcinogenesis has yet to be elucidated. Among de novo DNA methyltransferases (DNMTs), DNMT3B has lately been reported to act specifically on actively tra...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Iguchi, Eriko, Takai, Atsushi, Takeda, Haruhiko, Kumagai, Ken, Arasawa, Soichi, Eso, Yuji, Shimizu, Takahiro, Ueda, Yoshihide, Marusawa, Hiroyuki, Seno, Hiroshi
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7719166/
https://ncbi.nlm.nih.gov/pubmed/33277576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78151-2
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