Mutational spectrum of hepatitis C virus in patients with chronic hepatitis C determined by single molecule real-time sequencing

Abstract The emergence of hepatitis C virus (HCV) with resistance-associated substitution (RAS), produced by mutations in the HCV genome, is a major problem in direct acting antivirals (DAA) treatment. This study aimed to clarify the mutational spectrum in HCV-RNA and the substitution pattern for th...

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Hlavní autoři: Fumiyasu Nakamura, Haruhiko Takeda, Yoshihide Ueda, Atsushi Takai, Ken Takahashi, Yuji Eso, Soichi Arasawa, Eriko Iguchi, Takahiro Shimizu, Masako Mishima, Ken Kumagai, Taiki Yamashita, Shinji Uemoto, Nobuyuki Kato, Hiroyuki Marusawa, Akihiro Sekine, Hiroshi Seno
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Portfolio 2022-04-01
Edice:Scientific Reports
On-line přístup:https://doi.org/10.1038/s41598-022-11151-6
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