Single-molecular real-time deep sequencing reveals the dynamics of multi-drug resistant haplotypes and structural variations in the hepatitis C virus genome

While direct-acting antivirals (DAAs) for hepatitis C virus (HCV) have dramatically progressed, patients still suffer from treatment failures. For the radical eradication of HCV, a deeper understanding of multiple resistance-associated substitutions (RASs) at the single-clone level is essential. To...

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Udgivet i:Sci Rep
Main Authors: Yamashita, Taiki, Takeda, Haruhiko, Takai, Atsushi, Arasawa, Soichi, Nakamura, Fumiyasu, Mashimo, Yoichi, Hozan, Miyuki, Ohtsuru, Shigeru, Seno, Hiroshi, Ueda, Yoshihide, Sekine, Akihiro
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7021670/
https://ncbi.nlm.nih.gov/pubmed/32060395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59397-2
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