Targeting the ubiquitin‐proteasome system in a pancreatic cancer subtype with hyperactive MYC

The myelocytomatosis oncogene (MYC) is an important driver in a subtype of pancreatic ductal adenocarcinoma (PDAC). However, MYC remains a challenging therapeutic target; therefore, identifying druggable synthetic lethal interactions in MYC‐active PDAC may lead to novel precise therapies. First, to...

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Vydáno v:Mol Oncol
Hlavní autoři: Lankes, Katharina, Hassan, Zonera, Doffo, María Josefina, Schneeweis, Christian, Lier, Svenja, Öllinger, Rupert, Rad, Roland, Krämer, Oliver H., Keller, Ulrich, Saur, Dieter, Reichert, Maximilian, Schneider, Günter, Wirth, Matthias
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718946/
https://ncbi.nlm.nih.gov/pubmed/33099868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12835
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