MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib

The c-MYC (MYC afterward) oncogene is well known for driving numerous oncogenic programs. However, MYC can also induce apoptosis and this function of MYC warrants further clarification. We report here that a clinically relevant proteasome inhibitor significantly increases MYC protein levels and that...

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Detalhes bibliográficos
Main Authors: Wirth, Matthias, Stojanovic, Natasa, Christian, Jan, Paul, Mariel C., Stauber, Roland H., Schmid, Roland M., Häcker, Georg, Krämer, Oliver H., Saur, Dieter, Schneider, Günter
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176343/
https://ncbi.nlm.nih.gov/pubmed/25147211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku763
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