Chloroquine reverses chemoresistance via upregulation of p21(WAF1/CIP1) and autophagy inhibition in ovarian cancer

Overcoming drug-resistance is a big challenge to improve the survival of patients with epithelial ovarian cancer (EOC). In this study, we investigated the effect of chloroquine (CQ) and its combination with cisplatin (CDDP) in drug-resistant EOC cells. We used the three EOC cell lines CDDP-resistant...

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Publicat a:Cell Death Dis
Autors principals: Hwang, Jae Ryoung, Kim, Woo Young, Cho, Young-Jae, Ryu, Ji-Yoon, Choi, Jung-Joo, Jeong, Soo Young, Kim, Myeong-Sun, Kim, Ji Hye, Paik, E. Sun, Lee, Yoo-Young, Han, Hee-Dong, Lee, Jeong-Won
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718923/
https://ncbi.nlm.nih.gov/pubmed/33277461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03242-x
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