Chloroquine reverses chemoresistance via upregulation of p21(WAF1/CIP1) and autophagy inhibition in ovarian cancer

Overcoming drug-resistance is a big challenge to improve the survival of patients with epithelial ovarian cancer (EOC). In this study, we investigated the effect of chloroquine (CQ) and its combination with cisplatin (CDDP) in drug-resistant EOC cells. We used the three EOC cell lines CDDP-resistant...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Hwang, Jae Ryoung, Kim, Woo Young, Cho, Young-Jae, Ryu, Ji-Yoon, Choi, Jung-Joo, Jeong, Soo Young, Kim, Myeong-Sun, Kim, Ji Hye, Paik, E. Sun, Lee, Yoo-Young, Han, Hee-Dong, Lee, Jeong-Won
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718923/
https://ncbi.nlm.nih.gov/pubmed/33277461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03242-x
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