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Glycogen Synthase Kinase 3β Phosphorylates p21(WAF1/CIP1) for Proteasomal Degradation after UV Irradiation
UV irradiation has been reported to induce p21(WAF1/CIP1) protein degradation through a ubiquitin-proteasome pathway, but the underlying biochemical mechanism remains to be elucidated. Here, we show that ser-114 phosphorylation of p21 protein by glycogen synthase kinase 3β (GSK-3β) is required for i...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1899930/ https://ncbi.nlm.nih.gov/pubmed/17283049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01461-06 |
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