Loss of Nuclear p21(Cip1/WAF1) During Neoplastic Progression to Metastasis in γ-Irradiated p21 Hemizygous Mice

p21(Cip1/WAF1) localizes to the nucleus in response to γ-irradiation induced DNA damage and mediates a G(1) checkpoint arrest. Although γ-irradiated p21(+/-) mice develop a broad spectrum of tumors, γ-irradiated p21(-/-) mice develop significantly more metastatic cancers. To evaluate the expression...

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Bibliographic Details
Main Authors: Engelman, Robert W., Jackson, Rosalind J., Coppola, Domenico, Wharton, Walker, Cantor, Alan B., Jack Pledger, W.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2039892/
https://ncbi.nlm.nih.gov/pubmed/17207793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexmp.2006.10.007
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