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Loss of Nuclear p21(Cip1/WAF1) During Neoplastic Progression to Metastasis in γ-Irradiated p21 Hemizygous Mice
p21(Cip1/WAF1) localizes to the nucleus in response to γ-irradiation induced DNA damage and mediates a G(1) checkpoint arrest. Although γ-irradiated p21(+/-) mice develop a broad spectrum of tumors, γ-irradiated p21(-/-) mice develop significantly more metastatic cancers. To evaluate the expression...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2039892/ https://ncbi.nlm.nih.gov/pubmed/17207793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexmp.2006.10.007 |
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