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Evidence that EZH2 Deregulation is an Actionable Therapeutic Target for Prevention of Prostate Cancer

Chemoprevention trials for prostate cancer (PCa) by androgen receptor or androgen synthesis inhibition have proven ineffective. Recently, it has been demonstrated that the histone methlytransferase, EZH2 is de-regulated in mouse and human high-grade prostatic intraepithelial neoplasia (HG-PIN). Usin...

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Dettagli Bibliografici
Pubblicato in:Cancer Prev Res (Phila)
Autori principali: Burkhart, Deborah L., Morel, Katherine L., Wadosky, Kristine M., Labbé, David P., Galbo, Phillip M., Dalimov, Zafardjan, Xu, Bo, Loda, Massimo, Ellis, Leigh
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718322/
https://ncbi.nlm.nih.gov/pubmed/32917647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-20-0186
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