Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer

Histone H3 lysine 27 (H3K27M) mutations represent the canonical oncohistone, occurring frequently in midline gliomas but also identified in haematopoietic malignancies and carcinomas. H3K27M functions, at least in part, through widespread changes in H3K27 trimethylation but its role in tumour initia...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Pajovic, Sanja, Siddaway, Robert, Bridge, Taylor, Sheth, Javal, Rakopoulos, Patricia, Kim, Byungjin, Ryall, Scott, Agnihotri, Sameer, Phillips, Lauren, Yu, Man, Li, Christopher, Milos, Scott, Patel, Palak, Srikanthan, Dilakshan, Huang, Annie, Hawkins, Cynthia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718276/
https://ncbi.nlm.nih.gov/pubmed/33277484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19972-7
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