Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease

Myelin degeneration and white matter loss resulting from oligodendrocyte (OL) death are early events in Alzheimer’s disease (AD) that lead to cognitive deficits; however, the underlying mechanism remains unknown. Here, we find that mature OLs in both AD patients and an AD mouse model undergo NLR fam...

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Publicat a:Sci Adv
Autors principals: Zhang, Xinwen, Wang, Rihua, Hu, Di, Sun, Xiaoyan, Fujioka, Hisashi, Lundberg, Kathleen, Chan, Ernest R., Wang, Quanqiu, Xu, Rong, Flanagan, Margaret E., Pieper, Andrew A., Qi, Xin
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7717916/
https://ncbi.nlm.nih.gov/pubmed/33277246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb8680
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