Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease

Myelin degeneration and white matter loss resulting from oligodendrocyte (OL) death are early events in Alzheimer’s disease (AD) that lead to cognitive deficits; however, the underlying mechanism remains unknown. Here, we find that mature OLs in both AD patients and an AD mouse model undergo NLR fam...

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Pubblicato in:Sci Adv
Autori principali: Zhang, Xinwen, Wang, Rihua, Hu, Di, Sun, Xiaoyan, Fujioka, Hisashi, Lundberg, Kathleen, Chan, Ernest R., Wang, Quanqiu, Xu, Rong, Flanagan, Margaret E., Pieper, Andrew A., Qi, Xin
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2020
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7717916/
https://ncbi.nlm.nih.gov/pubmed/33277246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb8680
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