Resistance Outside the Substrate Envelope: Hepatitis C NS3/4A Protease Inhibitors

Direct acting antivirals have dramatically increased the efficacy and tolerability of hepatitis C treatment, but drug resistance has emerged with some of these inhibitors, including non-structural protein 3/4A protease inhibitors (PIs). Although many co-crystal structures of PIs with the NS3/4A prot...

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Bibliografiske detaljer
Udgivet i:Crit Rev Biochem Mol Biol
Main Authors: Özen, Ayşegül, Prachanronarong, Kristina, Matthew, Ashley N., Soumana, Djade I., Schiffer, Celia A.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7717897/
https://ncbi.nlm.nih.gov/pubmed/30821513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10409238.2019.1568962
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