Porcine SIRPA binds to human CD47 to inhibit phagocytosis: Implications for human hematopoietic stem cell transplantation into severe combined immunodeficient (SCID) pigs

BACKGROUND: Severe combined immunodeficient (SCID) pigs are an emerging animal model being developed for biomedical and regenerative medicine research. SCID pigs can successfully engraft human induced pluripotent stem cells and cancer cell lines. The development of a humanized SCID pig through xenot...

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Udgivet i:Xenotransplantation
Main Authors: Boettcher, Adeline N, Cunnick, Joan E, Powell, Ellis J, Egner, Timothy K, Charley, Sara E, Loving, Crystal L, Tuggle, Christopher K
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7717580/
https://ncbi.nlm.nih.gov/pubmed/30311702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/xen.12466
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