NK cells are intrinsically functional in pigs with Severe Combined Immunodeficiency (SCID) caused by spontaneous mutations in the Artemis gene

We have identified Severe Combined Immunodeficiency (SCID) in a line of Yorkshire pigs at Iowa State University. These SCID pigs lack B-cells and T-cells, but possess Natural Killer (NK) cells. This SCID phenotype is caused by recessive mutations in the Artemis gene. Interestingly, two human tumor c...

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Publicat a:Vet Immunol Immunopathol
Autors principals: Powell, Ellis J., Cunnick, Joan E., Knetter, Susan M., Loving, Crystal L., Waide, Emily H., Dekkers, Jack C.M., Tuggle, Christopher K.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5130348/
https://ncbi.nlm.nih.gov/pubmed/27269786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vetimm.2016.04.008
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