Development of Severe Combined Immunodeficient (SCID) Pig Models for Translational Cancer Modeling: Future Insights on How Humanized SCID Pigs Can Improve Preclinical Cancer Research

Within the last decade there have been several severe combined immunodeficient (SCID) pig models discovered or genetically engineered. The animals have mutations in ARTEMIS, IL2RG, or RAG1/2 genes, or combinations thereof, providing SCID pigs with NK cells, but deficient in T and B cells, or deficie...

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Udgivet i:Front Oncol
Main Authors: Boettcher, Adeline N., Loving, Crystal L., Cunnick, Joan E., Tuggle, Christopher K.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Oncology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284365/
https://ncbi.nlm.nih.gov/pubmed/30560086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00559
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