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Macrophage-secreted MMP9 induces mesenchymal transition in pancreatic cancer cells via PAR1 activation
PURPOSE: Targeting tumor-infiltrating macrophages limits progression and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma (PDAC). Protease-activated receptor (PAR)1 drives monocyte/macrophage recruitment, and stromal ablation of PAR1 limits cancer growth and enhances gemcitabi...
Gespeichert in:
| Veröffentlicht in: | Cell Oncol (Dordr) |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer Netherlands
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7717035/ https://ncbi.nlm.nih.gov/pubmed/32809114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13402-020-00549-x |
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