Macrophage-secreted MMP9 induces mesenchymal transition in pancreatic cancer cells via PAR1 activation

PURPOSE: Targeting tumor-infiltrating macrophages limits progression and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma (PDAC). Protease-activated receptor (PAR)1 drives monocyte/macrophage recruitment, and stromal ablation of PAR1 limits cancer growth and enhances gemcitabi...

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Publicado en:Cell Oncol (Dordr)
Autores principales: Tekin, Cansu, Aberson, Hella L, Waasdorp, Cynthia, Hooijer, Gerrit K J, de Boer, Onno J, Dijk, Frederike, Bijlsma, Maarten F, Spek, C Arnold
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Netherlands 2020
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Original Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7717035/
https://ncbi.nlm.nih.gov/pubmed/32809114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13402-020-00549-x
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