APOE ε4/ε4 homozygotes with early Alzheimer's disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline

INTRODUCTION: Hippocampal volume (HV) and cortical thickness are commonly used imaging biomarkers in Alzheimer's disease (AD) trials, and may have utility as selection criteria for enrichment strategies. Atrophy rates of these measures, in the high‐risk apolipoprotein E (APOE) ε4/ε4 homozygous...

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Vydáno v:Alzheimers Dement (N Y)
Hlavní autoři: Abushakra, Susan, Porsteinsson, Anton P., Sabbagh, Marwan, Bracoud, Luc, Schaerer, Joel, Power, Aidan, Hey, John A., Scott, David, Suhy, Joyce, Tolar, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7716452/
https://ncbi.nlm.nih.gov/pubmed/33304988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/trc2.12117
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