APOE ε4/ε4 homozygotes with early Alzheimer's disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline

INTRODUCTION: Hippocampal volume (HV) and cortical thickness are commonly used imaging biomarkers in Alzheimer's disease (AD) trials, and may have utility as selection criteria for enrichment strategies. Atrophy rates of these measures, in the high‐risk apolipoprotein E (APOE) ε4/ε4 homozygous...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Alzheimers Dement (N Y)
Prif Awduron: Abushakra, Susan, Porsteinsson, Anton P., Sabbagh, Marwan, Bracoud, Luc, Schaerer, Joel, Power, Aidan, Hey, John A., Scott, David, Suhy, Joyce, Tolar, Martin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2020
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7716452/
https://ncbi.nlm.nih.gov/pubmed/33304988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/trc2.12117
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