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Ubiquitin chains earmark GPCRs for BBSome-mediated removal from cilia
Regulated trafficking of G protein–coupled receptors (GPCRs) controls cilium-based signaling pathways. β-Arrestin, a molecular sensor of activated GPCRs, and the BBSome, a complex of Bardet–Biedl syndrome (BBS) proteins, are required for the signal-dependent exit of ciliary GPCRs, but the functional...
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| Опубликовано в: : | J Cell Biol |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Rockefeller University Press
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7716378/ https://ncbi.nlm.nih.gov/pubmed/33185668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202003020 |
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