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BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone

A diffusion barrier at the transition zone enables the compartmentalization of signaling molecules by cilia. The BBSome and the small guanosine triphosphatase Arl6, which triggers BBSome coat polymerization, are required for the exit of activated signaling receptors from cilia, but how diffusion bar...

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Bibliographic Details
Published in:J Cell Biol
Main Authors: Ye, Fan, Nager, Andrew R., Nachury, Maxence V.
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940304/
https://ncbi.nlm.nih.gov/pubmed/29483145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201709041
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