An actin network dispatches ciliary GPCRs into extracellular vesicles to modulate signaling

Signaling receptors dynamically exit cilia upon activation of signaling pathways such as Hedgehog. Here we find that when activated G protein coupled receptors (GPCRs) fail to undergo BBSome-mediated retrieval from cilia back into the cell, they concentrate into membranous buds at the tips of cilia...

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Publicado en:Cell
Main Authors: Nager, Andrew R., Goldstein, Jaclyn S., Herranz-Pérez, Vicente, Portran, Didier, Ye, Fan, Garcia-Verdugo, Jose Manuel, Nachury, Maxence V.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5235987/
https://ncbi.nlm.nih.gov/pubmed/28017328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.11.036
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