MBRS-26. CDK7 MEDIATED TRANSCRIPTIONAL PROCESSIVITY OF DNA REPAIR NETWORKS REGULATES SENSITIVITY TO RADIATION IN MYC DRIVEN MEDULLOBLASTOMA

Myc-driven Medulloblastoma remains a major therapeutic challenge due to frequent metastasis and a poor 5-year survival rate. Myc overexpression results in transcriptional dysregulation, proliferation, and survival of malignant cells. To identify therapeutic targets in Myc-amplified medulloblastoma w...

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Vydáno v:Neuro Oncol
Hlavní autoři: Veo, Bethany, Danis, Etienne, Fosmire, Susan, Wang, Dong, Pierce, Angela, Dahl, Nathan, Karam, Sana, Serkova, Natalie, Venkataraman, Sujatha, Vibhakar, Rajeev
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Medulloblastoma (Research)
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715894/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.541
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