MBRS-69. METABOLITE PROFILING OF SHH MEDULLOBLASTOMA IDENTIFIES A SUBSET OF CHILDHOOD TUMOURS ENRICHED FOR HIGH-RISK MOLECULAR BIOMARKERS AND CLINICAL FEATURES

SHH medulloblastoma patients have a variable prognosis. Infants (<3–5 years at diagnosis) are associated with a good prognosis, while disease-course in childhood is associated with specific prognostic biomarkers (MYCN amplification, TP53 mutation, LCA histology; all high-risk). There is an unmet...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Bennett, Christopher, Kohe, Sarah, Burte, Florence, Rose, Heather, Hicks, Debbie, Schwalbe, Ed, Crosier, Stephen, Storer, Lisa, Lourdusamy, Anbarasu, Wilson, Martin, Avula, Shivaram, Mitra, Dipayan, Dineen, Robert, Bailey, Simon, Williamson, Daniel, Grundy, Richard, Clifford, Steven, Peet, Andrew
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Medulloblastoma (Research)
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715738/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.573
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