TBIO-08. BASE-RESOLUTION METHYLOMES OF GLIOMAS BEARING HISTONE H3.3 MUTATIONS REVEAL A G34 MUTANT-SPECIFIC SIGNATURE SHARED WITH BONE TUMORS

BACKGROUND: Two recurrent mutations, K27M and G34R/V, in H3F3A, encoding non-canonical histone H3.3, are reported in pediatric and young adult gliomas, whereas G34W mutation was prevalent in bone tumors. In contrast to K27 mutation, it remains elusive how G34 mutations affect the epigenome. Here we...

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Библиографические подробности
Опубликовано в: :Neuro Oncol
Главные авторы: Sangatsuda, Yuhei, Miura, Fumihito, Araki, Hiromitsu, Mizuguchi, Masahiro, Hata, Nobuhiro, Kuga, Daisuke, Hatae, Ryusuke, Akagi, Yojiro, Amemiya, Takeo, Fujioka, Yutaka, Arai, Yasuhito, Shibata, Tatsuhiro, Yoshimoto, Koji, Ito, Takashi, Iihara, Koji
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2020
Предметы:
Tumor Biology (not fitting a specific disease category)
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715604/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.836
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