Base-resolution methylomes of gliomas bearing histone H3.3 mutations reveal a G34 mutant-specific signature shared with bone tumors

Two recurrent mutations, K27M and G34R/V, in H3F3A, encoding non-canonical histone H3.3, are reported in pediatric and young adult gliomas, whereas G34W mutation is prevalent in bone tumors. In contrast to K27M mutation, it remains elusive how G34 mutations affect the epigenome. Here we performed wh...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Sangatsuda, Yuhei, Miura, Fumihito, Araki, Hiromitsu, Mizoguchi, Masahiro, Hata, Nobuhiro, Kuga, Daisuke, Hatae, Ryusuke, Akagi, Yojiro, Amemiya, Takeo, Fujioka, Yutaka, Arai, Yasuhito, Yoshida, Akihiko, Shibata, Tatsuhiro, Yoshimoto, Koji, Iihara, Koji, Ito, Takashi
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7527345/
https://ncbi.nlm.nih.gov/pubmed/32999376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73116-x
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