Base-resolution methylomes of gliomas bearing histone H3.3 mutations reveal a G34 mutant-specific signature shared with bone tumors

Two recurrent mutations, K27M and G34R/V, in H3F3A, encoding non-canonical histone H3.3, are reported in pediatric and young adult gliomas, whereas G34W mutation is prevalent in bone tumors. In contrast to K27M mutation, it remains elusive how G34 mutations affect the epigenome. Here we performed wh...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Sangatsuda, Yuhei, Miura, Fumihito, Araki, Hiromitsu, Mizoguchi, Masahiro, Hata, Nobuhiro, Kuga, Daisuke, Hatae, Ryusuke, Akagi, Yojiro, Amemiya, Takeo, Fujioka, Yutaka, Arai, Yasuhito, Yoshida, Akihiko, Shibata, Tatsuhiro, Yoshimoto, Koji, Iihara, Koji, Ito, Takashi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7527345/
https://ncbi.nlm.nih.gov/pubmed/32999376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73116-x
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi